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Sickle cell trait is an inherited blood disorder that affects 1 million to 3 million Americans and 8 to 10 percent of African Americans.

Occasionally people with sickle cell trait can have blood in their urine.

Under extreme conditions such as high altitude, severe dehydration, or very high intensity physical activity, red cells can become deformed or sickled.

Complications include muscle breakdown (rhabdomyolysis), reduced blood supply to the spleen (ischemia/infarction), or increased pressure in the eye (glaucoma) following eye injuries.

Finally, a very rare form of kidney cancer (renal medullary carcinoma) has been associated with sickle cell trait.

back to top Sickle cell trait is more common in certain ethnic groups, including: All newborns in the United States are now tested for sickle cell disease and sickle cell trait.

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